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Selected: Default · set 4, System 16B, unprotected

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Alien Syndrome (set 4, System 16B, unprotected)

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Alien Syndrome

What is Alien Syndrome?

This is an action RPG from the Alien Syndrome franchise, originally released in 2007 for the PlayStation Portable and Wii. Developed by Totally Games, it takes place a century after the earlier arcade entries and marks a shift in genre by incorporating leveling, equipment, and skill progression. The version here, labeled as "set 4, System 16B, unprotected," is one of several dumps available on arcade emulation sites, though it's important to note this is originally a handheld/console title rather than a classic coin-op.

As the player, you guide a character through a series of sci-fi environments, blasting alien creatures and collecting loot. The core gameplay involves real-time combat mixed with RPG mechanics: you gain experience, improve your character's stats, and unlock new abilities as you progress. The game encourages exploration and backtracking to find better gear and secrets, while straightforward quest objectives push the story forward.

For fans of the Alien Syndrome series, this entry offers a fresh take by blending traditional run-and-gun action with deeper character customization. It's a decent action RPG for its time, but the shift away from pure arcade shooting might not appeal to everyone. If you enjoy games like Phantasy Star Online or the later 2D action RPGs of the mid-2000s, this is worth a look - just keep in mind that the controls and presentation are adapted from portable systems.

GAME INFO

Platform
Arcade
Genre
RPG
Publisher
Sega
Developer
Totally Games
Released
2007
Version
set 4 (System 16B, unprotected)

How to play Alien Syndrome online



This is an action RPG, so your first goal is to get familiar with the controls. Use the Arrow Keys to move your character around the map. Press X to attack enemies with your current weapon or interact with objects and NPCs. The B button (S) can be used to run or cancel selections. Open the inventory by pressing A (X button) to equip new gear or use items. Start (Enter) pauses the game and brings up the menu where you can view your progress, skills, and quest log. Select (V) may toggle a map or additional info.

As you explore, you'll encounter alien creatures that drop loot and experience. Defeat them, grab their drops, and keep an eye on your health bar. You can level up your character by earning enough XP, which unlocks new abilities and improves your stats. The game encourages revisiting earlier areas with better gear to find hidden paths or items. If you get stuck, look for quest markers or talk to every NPC - many give hints or side objectives. Menus are in English, so navigation should be straightforward.

CONTROLS

Controls

  • Arrow Keys: Joystick / Movement
  • X: Button 1
  • S: Button 2
  • Z: Button 3
  • A: Button 4
  • Q: Button 5
  • E: Button 6
  • Enter: Start / 1P
  • V: Coin / Insert

Alien Syndrome FAQ

Who developed Alien Syndrome?

Totally Games developed this 2007 iteration of Alien Syndrome for the PlayStation Portable and Wii. The franchise itself was originally created by Sega.

Is there anything iconic or memorable about Alien Syndrome?

This version is notable for shifting the series from its arcade roots into an action RPG with leveling and loot systems. It also expands the lore by setting the story a century after the original games.

Is Alien Syndrome exclusive to Arcade or did it appear on other systems?

It originally launched on PlayStation Portable and Wii. The arcade version seen here is a reproduction or emulated dump of that same game, not the 1988 arcade original.

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